Sex Hormone Binding Globulin (SHBG) Test

The Sex Hormone Binding Globulin (SHBG) test is a blood test that measures the level of SHBG in the bloodstream. SHBG is a protein produced primarily by the liver, and it plays a crucial role in regulating the availability of sex hormones such as testosterone and estrogen. By binding to these hormones, SHBG controls their bioavailability and the extent to which they can exert biological effects in the body. Changes in SHBG levels can provide important insights into various medical conditions, including hormonal imbalances, metabolic disorders, and other health issues affecting men and women.

The SHBG test is often ordered when a healthcare provider suspects abnormal hormone levels that may be impacting a patient’s health. For men, this may relate to symptoms such as reduced libido, erectile dysfunction, or unexplained weight gain. For women, the test may be used to investigate issues such as irregular menstrual cycles, infertility, or symptoms of polycystic ovary syndrome (PCOS). Results from the SHBG test can aid in the diagnosis and management of these conditions, allowing healthcare providers to tailor treatments according to an individual’s hormonal profile.

Interpreting SHBG levels requires a comprehensive understanding of the broader hormonal milieu. Factors such as age, weight, sex, and certain medications can influence SHBG concentrations. Higher SHBG levels are often associated with increased estrogen levels, hyperthyroidism, and liver disease, while lower levels can indicate conditions such as obesity, insulin resistance, and hypothyroidism. Overall, the SHBG test serves as a valuable tool in endocrinology, helping to elucidate complex hormonal interactions and guide effective treatment strategies for various health conditions.